Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 6/20 | 0.57 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18216619 | 0.87 | TDP1 (0.58) | TDP1HTTLCKALDH1A1KMT2A | |
| SCHEMBL2586412 | 0.84 | TDP1 (0.63) | TDP1HTTLCKALDH1A1KMT2A | |
| SCHEMBL8964829 | 0.83 | TDP1 (0.62) | TDP1HTTLCKALDH1A1KMT2A | |
| SCHEMBL8973475 | 0.83 | TDP1 (0.62) | TDP1HTTLCKALDH1A1KMT2A | |
| SCHEMBL28941115 | 0.82 | TDP1 (0.53) | TDP1HTTLCKALDH1A1KMT2A | |
| SCHEMBL18213804 | 0.82 | TDP1 (0.53) | TDP1HTTLCKALDH1A1KMT2A | |
| SCHEMBL922726 | 0.81 | TDP1 (0.58) | TDP1HTTLCKALDH1A1KMT2A | |
| SCHEMBL4652150 | 0.81 | TDP1 (0.58) | TDP1HTTLCKALDH1A1KMT2A | |
| SCHEMBL3749821 | 0.81 | TDP1 (0.58) | TDP1HTTLCKALDH1A1KMT2A | |
| SCHEMBL3749823 | 0.81 | TDP1 (0.58) | TDP1HTTLCKALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716346-B2 | Alkylating agent combinations in the treatment of cancer | CASE WESTERN RESERVE UNIVERSITY (US) | 2014-05-06 | — | — | US | disclosed |
| US-8716346-B2 | Alkylating agent combinations in the treatment of cancer | CASE WESTERN RESERVE UNIVERSITY (US) | 2014-05-06 | — | — | US | disclosed |
| US-8324282-B2 | Alkylating agent combinations in the treatment of cancer | CASE WESTERN RESERVE UNIVERSITY (US) | 2012-12-04 | — | — | US | disclosed |
| US-20120065145-A1 | ALKYLATING AGENT COMBINATIONS IN THE TREATMENT OF CANCER | GERSON STANTON L (US) | 2012-03-15 | — | — | US | disclosed |
| US-8017618-B2 | Administering antifolate anticancer agent and methoxyamine to enhance or increase the effect of the antifolate anticancer agent | TRACON PHARMACEUTICALS, INC. (US) | 2011-09-13 | — | — | US | disclosed |
| US-20080234298-A1 | ANTIFOLATE AGENT COMBINATIONS IN THE TREATMENT OF CANCER | TRACON PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065145-A1 | ALKYLATING AGENT COMBINATIONS IN THE TREATMENT OF CANCER | UNG, TOP2A, OGG1 | TDP1 107/4885IDO1 4025/4885HTT 4496/4885 |
| US-20080234298-A1 | ANTIFOLATE AGENT COMBINATIONS IN THE TREATMENT OF CANCER | FEN1, UNG, FOLR1 | TDP1 441/4885IDO1 3342/4885HTT 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.