SCHEMBL4032680

SCHEMBL4032680

CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)N1CCCCCl

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PGR P06401 1/20 0.81
AR P10275 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL633929 0.94 AR (0.88) PGRAR
SCHEMBL4025147 0.93 AR (0.76) PGRAR
Ru-58841 SCHEMBL1461459 0.90 AR (1.00) PGRAR
SCHEMBL7786228 0.90 AR (0.81) PGRAR
Ru-58841 SCHEMBL29372187 0.90 AR (1.00) PGRAR
SCHEMBL5579470 0.90 AR (0.81) PGRAR
SCHEMBL4025722 0.89 AR (0.98) PGRAR
SCHEMBL630193 0.89 AR (0.80) PGRAR
SCHEMBL7781110 0.89 AR (0.80) PGRAR
SCHEMBL2694365 0.89 AR (0.94) PGRAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009097996-A1 USE OF SUBSTITUTED PHENYLIMIDAZOLIDINES FOR PRODUCING MEDICAMENTS FOR TREATING METABOLIC SYNDROME SANOFI-AVENTIS (FR) 2009-08-13 WO disclosed
EP-0671156-B1 Process to prepare cosmetic or pharmaceutical compositions containing liposomes AVENTIS PHARMA SA (FR) 2001-10-24 EP disclosed
US-6162444-A Cosmetic or pharmaceutical compositions HOECHST MARION ROUSSEL (FR) 2000-12-19 US disclosed
US-5627201-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1997-05-06 US disclosed
EP-0671156-A1 Cosmetic or pharmaceutical compositions containing liposomes ROUSSEL UCLAF (FR) 1995-09-13 EP disclosed
US-5411981-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1995-05-02 US disclosed
EP-0580459-A1 Substituted Phenylimidazolidins, process for their preparation, their use as medicaments and their pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1994-01-26 EP disclosed