Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | HCK | P08631 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.52 |
| ▸ | MTOR | P42345 | 3/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.52 |
| ▸ | PRKDC | P78527 | 3/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030110 | 0.81 | ESR1 (0.43) | EGFRABL1HCKSRCKDR | |
| SCHEMBL4029667 | 0.76 | ESR1 (0.53) | EGFRABL1HCKSRCKDR | |
| SCHEMBL5397335 | 0.76 | ESR1 (0.51) | EGFRABL1HCKSRCKDR | |
| SCHEMBL4026032 | 0.72 | ESR1 (0.60) | EGFRABL1HCKSRCKDR | |
| SCHEMBL4026000 | 0.71 | ESR1 (0.73) | EGFRABL1HCKSRCKDR | |
| SCHEMBL4030477 | 0.70 | ESR1 (0.70) | EGFRABL1HCKSRCKDR | |
| SCHEMBL31140840 | 0.68 | ESR1 (0.38) | ESR1SMN1; SMN2MPOALDH1A1LMNA | |
| SCHEMBL18212231 | 0.68 | ESR1 (0.41) | ESR1SMN1; SMN2MPOALDH1A1LMNA | |
| SCHEMBL3613209 | 0.68 | SRC (1.00) | EGFRABL1HCKSRCKDR | |
| SCHEMBL6698490 | 0.68 | ESR1 (0.53) | EGFRABL1HCKSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | disclosed |