Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032294 | 0.90 | HRH3 (0.53) | HRH3ACKR3 | |
| SCHEMBL4031748 | 0.87 | HRH3 (0.53) | HRH3KCNH2ACKR3 | |
| SCHEMBL5210405 | 0.87 | HRH3 (0.61) | HRH3 | |
| SCHEMBL4032242 | 0.84 | HRH3 (0.55) | HRH3 | |
| SCHEMBL4036526 | 0.83 | HRH3 (0.54) | HRH3 | |
| SCHEMBL4032479 | 0.81 | HRH3 (0.53) | HRH3KCNH2 | |
| SCHEMBL24420935 | 0.80 | KDM4E (0.43) | HRH3USP2 | |
| SCHEMBL29614700 | 0.80 | KDM4E (0.43) | HRH3USP2 | |
| Hydrochloric Acid SCHEMBL26114917 | 0.79 | KDM4E (0.42) | HRH3USP2 | |
| SCHEMBL1749370 | 0.79 | USP2 (0.60) | HRH3USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789410-B1 | METHYLENE DIPIPERIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2009-06-17 | — | — | EP | claimed |