Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.69 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5397660 | 0.86 | ESR1 (0.65) | ESR1RORCLMNAKMT2ANPSR1 | |
| SCHEMBL4031726 | 0.82 | ESR1 (1.00) | ESR1RORCLMNAKMT2ANPSR1 | |
| SCHEMBL4032737 | 0.80 | ESR1 (0.69) | ESR1SLC22A12RORCKMT2ANPSR1 | |
| SCHEMBL4031909 | 0.79 | ESR1 (0.76) | ESR1RORCNPSR1ALDH1A1L3MBTL1 | |
| SCHEMBL4029785 | 0.79 | ESR1 (0.68) | ESR1RORCLMNAKMT2ANPSR1 | |
| SCHEMBL4027997 | 0.78 | ESR1 (0.73) | ESR1RORCKMT2ANPSR1MEN1 | |
| SCHEMBL4026618 | 0.77 | ESR1 (0.73) | ESR1RORCLMNAKMT2ANPSR1 | |
| SCHEMBL4029031 | 0.76 | ESR1 (0.63) | ESR1RORCLMNAKMT2ANPSR1 | |
| SCHEMBL4030292 | 0.75 | ESR1 (1.00) | ESR1RORCKMT2ANPSR1MEN1 | |
| SCHEMBL4030848 | 0.75 | ESR1 (0.65) | ESR1KMT2ANPSR1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | claimed |