Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.69 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5397655 | 0.83 | ESR1 (0.64) | ESR1HSD17B10RORCTP53MEN1 | |
| SCHEMBL4031726 | 0.82 | ESR1 (1.00) | ESR1KDM4ETSHRHSD17B10RORC | |
| SCHEMBL4032735 | 0.80 | ESR1 (0.69) | ESR1SLC22A12RORCTP53MEN1 | |
| SCHEMBL4027997 | 0.78 | ESR1 (0.73) | ESR1KDM4ERORCTP53MEN1 | |
| SCHEMBL5397660 | 0.78 | ESR1 (0.65) | ESR1KDM4ERORCTP53MEN1 | |
| SCHEMBL4026618 | 0.77 | ESR1 (0.73) | ESR1TSHRRORCTP53MEN1 | |
| SCHEMBL4029031 | 0.76 | ESR1 (0.63) | ESR1KDM4ETSHRRORCTP53 | |
| SCHEMBL4030292 | 0.75 | ESR1 (1.00) | ESR1KDM4ETSHRHSD17B10RORC | |
| SCHEMBL4026981 | 0.74 | ESR1 (0.93) | ESR1RORCTP53MEN1KMT2A | |
| SCHEMBL4025562 | 0.74 | ESR1 (0.71) | ESR1RORCALDH1A1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | claimed |