Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.54 |
| ▸ | KDR | P35968 | 9/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939418 | 0.85 | IGF1R (0.63) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4025368 | 0.82 | IGF1R (0.67) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4016403 | 0.82 | IGF1R (0.66) | IGF1RFGFR1KDRINSR | |
| SCHEMBL3934000 | 0.81 | IGF1R (0.65) | IGF1RFGFR1KDR | |
| SCHEMBL4161724 | 0.81 | IGF1R (0.65) | IGF1RFGFR1KDR | |
| SCHEMBL4032312 | 0.81 | IGF1R (0.52) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4011985 | 0.80 | IGF1R (0.47) | IGF1RFGFR1KDRJAK2JAK3 | |
| SCHEMBL4306964 | 0.80 | IGF1R (0.54) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4011962 | 0.80 | IGF1R (0.54) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4009925 | 0.79 | IGF1R (0.47) | IGF1RFGFR1KDRJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009019518-A1 | PYRIMIDINE COMPOUNDS HAVING A FGFR INHIBITORY EFFECT | ASTRAZENECA AB (SE) | 2009-02-12 | — | — | WO | disclosed |