Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.52 |
| ▸ | KDR | P35968 | 10/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033236 | 0.86 | IGF1R (0.57) | IGF1RFGFR1KDRINSRLMNA | |
| SCHEMBL4032661 | 0.86 | IGF1R (0.59) | IGF1RFGFR1KDRINSRPLK4 | |
| SCHEMBL4025368 | 0.85 | IGF1R (0.67) | IGF1RFGFR1KDRINSRLMNA | |
| SCHEMBL4032918 | 0.81 | IGF1R (0.54) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4026982 | 0.78 | IGF1R (0.55) | IGF1RFGFR1KDRINSR | |
| SCHEMBL5103677 | 0.77 | IGF1R (0.56) | IGF1RFGFR1KDRINSR | |
| SCHEMBL3950749 | 0.77 | IGF1R (0.67) | IGF1RFGFR1KDRINSRLMNA | |
| SCHEMBL5100446 | 0.74 | IGF1R (0.54) | IGF1RFGFR1KDRINSR | |
| Hydrochloric Acid SCHEMBL5110827 | 0.74 | IGF1R (0.53) | IGF1RFGFR1KDRINSR | |
| SCHEMBL5109603 | 0.74 | IGF1R (0.53) | IGF1RFGFR1KDRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009019518-A1 | PYRIMIDINE COMPOUNDS HAVING A FGFR INHIBITORY EFFECT | ASTRAZENECA AB (SE) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009019518-A1 | PYRIMIDINE COMPOUNDS HAVING A FGFR INHIBITORY EFFECT | ASTRAZENECA AB (SE) | 2009-02-12 | — | — | WO | disclosed |