Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 17/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033550 | 0.82 | CYP17A1 (0.70) | CYP17A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4029187 | 0.79 | CYP17A1 (0.40) | CYP17A1CYP2C8CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4025067 | 0.78 | CYP17A1 (0.42) | CYP17A1CYP2C8CYP3A4IMPDH2IMPDH1 | |
| SCHEMBL5753809 | 0.77 | CYP3A4 (0.47) | CYP17A1CYP2C8CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4030492 | 0.76 | CYP17A1 (0.52) | CYP17A1CYP2C8CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4030366 | 0.74 | CYP17A1 (0.68) | CYP17A1CYP2C8CYP3A4 | |
| SCHEMBL4028482 | 0.74 | CYP17A1 (0.37) | CYP17A1CYP2C8CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7539165 | 0.73 | CYP17A1 (0.38) | CYP17A1CYP2C8CYP3A4IMPDH2 | |
| SCHEMBL5753882 | 0.72 | CYP3A4 (0.44) | CYP17A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1415155 | 0.71 | CYP17A1 (0.42) | CYP17A1CYP2C8CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222174-B1 | IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE | TAKEDA PHARMACEUTICAL (JP) | 2009-05-27 | — | — | EP | disclosed |
| US-6649643-B1 | Antitumor, anticarcinogenic, and antimetastasis agents; benign prostatic hyperplasia, alopecia, endometriosis, uterine myoma, hirsutism, virilism, precocious puberty, mastopathy, and polycystic overay syndrome treatment | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-11-18 | — | — | US | disclosed |
| EP-1222174-A1 | IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE | Takeda Chemical Industries, Ltd. (JP) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001030762-A1 | IMIDAZOL-4-YLMETHANOLS USE AS INHIBITORS OF STEROID C17-20 LYASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-03 | — | — | WO | disclosed |