Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.55 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.49 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 3/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | SGK1 | O00141 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031734 | 0.87 | GSTO1 (0.54) | MCOLN3GSTO1HSD11B1ALDH1A1KMT2A | |
| SCHEMBL7847967 | 0.86 | MCOLN3 (0.56) | MCOLN3GSTO1BDKRB1HSD11B1ALDH1A1 | |
| SCHEMBL12010352 | 0.86 | MCOLN3 (0.56) | MCOLN3BDKRB1HSD11B1ALDH1A1KMT2A | |
| SCHEMBL3439979 | 0.84 | MCOLN3 (0.55) | MCOLN3GSTO1BDKRB1HSD11B1ALDH1A1 | |
| SCHEMBL4033897 | 0.82 | GSTO1 (0.46) | MCOLN3GSTO1BDKRB1HSD11B1ALDH1A1 | |
| SCHEMBL5383623 | 0.82 | MCOLN3 (0.52) | MCOLN3BDKRB1HSD11B1ALDH1A1KMT2A | |
| SCHEMBL15314381 | 0.82 | MCOLN3 (0.52) | MCOLN3BDKRB1HSD11B1ALDH1A1KMT2A | |
| SCHEMBL5111158 | 0.81 | MCOLN3 (0.52) | MCOLN3GSTO1BDKRB1HSD11B1ALDH1A1 | |
| SCHEMBL5393186 | 0.80 | MCOLN3 (0.51) | MCOLN3GSTO1BDKRB1HSD11B1ALDH1A1 | |
| SCHEMBL5115197 | 0.80 | MCOLN3 (0.51) | MCOLN3GSTO1BDKRB1HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521744-B1 | ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS B1 BRADYKININ RECEPTOR ANTAGONISTS | FOURNIER LAB SA (FR) | 2009-04-01 | — | — | EP | disclosed |
| US-7361687-B2 | Arylsulphonamide derivatives and methods of preparing | LABORATOIRES FOURNIER SA (FR) | 2008-04-22 | — | — | US | disclosed |
| US-20060084699-A1 | Novel arylsulphonamide derivatives and use thereof as therapeutic agents | LABORATOIRES FOURNIER SA (FR) | 2006-04-20 | — | — | US | disclosed |
| EP-1521744-A1 | ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS B1 BRADYKININ RECEPTOR ANTAGONISTS | LABORATOIRES FOURNIER S.A. (FR) | 2005-04-13 | — | — | EP | disclosed |
| WO-2003106428-A1 | NOVEL ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS THERAPEUTIC AGENTS | LABORATOIRES FOURNIER SA (FR) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084699-A1 | Novel arylsulphonamide derivatives and use thereof as therapeutic agents | UGT1A1, UGT2B7, UGT1A6 | MCOLN3 4434/4885GSTO1 392/4885BDKRB1 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.