Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4033517 | 0.94 | EGFR (0.70) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4034609 | 0.89 | EGFR (1.00) | EGFRERBB2SRC | |
| SCHEMBL4213030 | 0.87 | EGFR (0.77) | EGFRERBB2 | |
| SCHEMBL4040179 | 0.87 | EGFR (1.00) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4034340 | 0.86 | EGFR (0.83) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4036009 | 0.85 | EGFR (0.81) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4031827 | 0.85 | EGFR (0.81) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4037607 | 0.85 | EGFR (0.84) | EGFRERBB2KCNH2 | |
| SCHEMBL4032825 | 0.85 | EGFR (0.78) | EGFRERBB2KCNH2SRC | |
| SCHEMBL4036214 | 0.85 | EGFR (0.83) | EGFRERBB2KCNH2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |