Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 6/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.46 |
| ▸ | ATXN2 | Q99700 | 4/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2471729 | 0.88 | GRIN2B (0.59) | OPRD1OPRK1GRIN2BENPP2ATXN2 | |
| SCHEMBL2468686 | 0.79 | KMT2A (0.52) | OPRD1OPRK1OPRM1SMN1; SMN2CYP2C19 | |
| SCHEMBL2473564 | 0.73 | EPHX2 (0.44) | OPRD1OPRK1ENPP2ATXN2OPRM1 | |
| SCHEMBL2702761 | 0.71 | GRIN2B (0.66) | OPRD1OPRK1GRIN2BENPP2ATXN2 | |
| SCHEMBL19970834 | 0.70 | GRIN2B (0.49) | GRIN2BENPP2ATXN2HDAC3HDAC1 | |
| SCHEMBL2709670 | 0.70 | GRIN2B (0.56) | GRIN2BSMN1; SMN2CYP2C19MEN1KMT2A | |
| SCHEMBL56293 | 0.70 | OPRD1 (0.58) | OPRD1OPRK1GRIN2BENPP2ATXN2 | |
| SCHEMBL2493036 | 0.69 | GRIN2B (0.56) | OPRD1OPRK1GRIN2BENPP2ATXN2 | |
| SCHEMBL934263 | 0.69 | MEN1 (0.64) | OPRD1OPRK1GRIN2BENPP2ATXN2 | |
| SCHEMBL2465403 | 0.69 | OPRD1 (0.54) | OPRD1OPRK1ENPP2ATXN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501467-A4 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1501467-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | Bristol-Myers Squibb Company (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003088908-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-10-30 | — | — | WO | disclosed |