Sugi Predict

Sugi Predict / Compounds / SCHEMBL4033637

SCHEMBL4033637

SCHEMBL4033637

CC1(C)C(=O)N(c2ccc(SC(F)(F)F)cc2)C(=O)N1Cc1ccnc(CC(N)=O)c1

nearest known ligand 0.80

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 19/20 0.80
▸ PPARG P37231 1/20 0.42
▸ PPARD Q03181 1/20 0.42
▸ PPARA Q07869 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2931286 0.89 IGF1R (1.00) IGF1RPPARGPPARDPPARA
SCHEMBL3727581 0.89 IGF1R (0.84) IGF1R
SCHEMBL2940044 0.89 IGF1R (0.84) IGF1R
SCHEMBL2931858 0.88 IGF1R (1.00) IGF1R
SCHEMBL2935235 0.86 IGF1R (1.00) IGF1R
Trifluoroacetic Acid SCHEMBL2939211 0.86 IGF1R (0.93) IGF1RPPARGPPARDPPARA
SCHEMBL2931731 0.86 IGF1R (0.85) IGF1R
SCHEMBL2941359 0.85 IGF1R (0.86) IGF1R
SCHEMBL2939508 0.85 IGF1R (0.81) IGF1R
SCHEMBL2939949 0.85 IGF1R (0.86) IGF1RPPARGPPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2035408-A1 SULPHUR-CONTAINING CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2009-03-18 — — EP disclosed
WO-2008000922-A1 SULPHUR-CONTAINING CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2008-01-03 — — WO disclosed