Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.73 |
| ▸ | CCKBR | P32239 | 2/20 | 0.72 |
| ▸ | KIF11 | P52732 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1195763 | 1.00 | PDE5A (0.73) | PDE5ACCKBRKIF11KDM4ETSHR | |
| SCHEMBL4034976 | 1.00 | PDE5A (0.73) | PDE5ACCKBRKIF11KDM4ETSHR | |
| SCHEMBL1197087 | 1.00 | PDE5A (0.73) | PDE5ACCKBRKIF11KDM4ETSHR | |
| SCHEMBL1922013 | 0.89 | CCKBR (0.78) | PDE5ACCKBRKIF11KDM4ETSHR | |
| SCHEMBL1921528 | 0.89 | CCKBR (0.85) | PDE5ACCKBRKDM4ETSHRHSD17B10 | |
| SCHEMBL17760646 | 0.89 | CCKBR (0.85) | PDE5ACCKBRKDM4ETSHRHSD17B10 | |
| SCHEMBL16489366 | 0.89 | CCKBR (0.85) | PDE5ACCKBRKDM4ETSHRHSD17B10 | |
| SCHEMBL4600163 | 0.89 | CCKBR (0.85) | PDE5ACCKBRKDM4ETSHRHSD17B10 | |
| SCHEMBL13402875 | 0.89 | CCKBR (0.85) | PDE5ACCKBRKDM4ETSHRHSD17B10 | |
| SCHEMBL1921583 | 0.89 | CCKBR (0.85) | PDE5ACCKBRKDM4ETSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033962-A1 | Tetracyclic indolopyridines as EG5 inhibitors | 4SC AG (DE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2009024613-A1 | TETRACYCLIC INDOLOPYRIDINES AS EG5 INHIBITORS | 4SC AG (DE) | 2009-02-26 | — | — | WO | disclosed |