Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 6/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.41 |
| ▸ | RAF1 | P04049 | 4/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.35 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025068 | 0.89 | GRIN2B (0.47) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL4027146 | 0.82 | AKT1 (0.49) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL8603594 | 0.80 | TMEM97 (0.42) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL4028496 | 0.80 | NPC1 (0.46) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL4026457 | 0.80 | DRD4 (0.51) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL4025941 | 0.78 | DRD2 (0.47) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL4025897 | 0.77 | MAPK14 (0.51) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL13810996 | 0.77 | MAPK11 (0.46) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL4026568 | 0.76 | CSNK1A1 (0.52) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL13810833 | 0.75 | BRAF (0.47) | MAPK11MAPK14MAPK13MAPK12RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854870-B1 | SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2009-06-10 | — | — | EP | claimed |