Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.78 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.78 |
| ▸ | KDR | P35968 | 10/20 | 0.78 |
| ▸ | INSR | P06213 | 5/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3871585 | 0.88 | IGF1R (0.78) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL2121130 | 0.88 | IGF1R (1.00) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL2122449 | 0.84 | IGF1R (0.78) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL2123793 | 0.82 | IGF1R (0.78) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL3932980 | 0.81 | IGF1R (0.74) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4038016 | 0.77 | IGF1R (0.79) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4037341 | 0.77 | IGF1R (0.59) | IGF1RFGFR1KDRNTRK1 | |
| SCHEMBL2121493 | 0.76 | IGF1R (1.00) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4041620 | 0.75 | NTRK1 (0.46) | IGF1RFGFR1KDRNTRK1 | |
| SCHEMBL4012116 | 0.74 | IGF1R (0.74) | IGF1RFGFR1KDRINSRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |