Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.79 |
| ▸ | KDR | P35968 | 5/20 | 0.79 |
| ▸ | BCL6 | P41182 | 2/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038423 | 0.88 | IGF1R (1.00) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4034569 | 0.87 | IGF1R (0.66) | IGF1RFGFR1KDRBCL6INSR | |
| SCHEMBL2122674 | 0.84 | IGF1R (0.58) | IGF1RFGFR1KDRBCL6INSR | |
| SCHEMBL4037341 | 0.84 | IGF1R (0.59) | IGF1RFGFR1KDRNTRK1AURKA | |
| SCHEMBL4031791 | 0.83 | IGF1R (0.79) | IGF1RFGFR1KDRBCL6INSR | |
| SCHEMBL27522808 | 0.77 | IGF1R (0.48) | IGF1RFGFR1KDRNTRK1PRKAB2 | |
| SCHEMBL4033911 | 0.77 | IGF1R (0.78) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4041620 | 0.75 | NTRK1 (0.46) | IGF1RFGFR1KDRNTRK1PRKAB2 | |
| SCHEMBL2123750 | 0.74 | IGF1R (0.85) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4036281 | 0.73 | IGF1R (0.85) | IGF1RFGFR1KDRINSRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |