Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.45 |
| ▸ | SRC | P12931 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5664057 | 0.99 | EGFR (0.44) | EGFRERBB2SRCKCNH2KDR | |
| SCHEMBL6313281 | 0.82 | EGFR (0.48) | EGFRERBB2SRCKCNH2KDR | |
| SCHEMBL5475801 | 0.72 | EGFR (0.54) | EGFRERBB2SRCKCNH2KDR | |
| Hydrochloric Acid SCHEMBL4034029 | 0.72 | EGFR (0.70) | EGFRERBB2SRCKCNH2KDR | |
| SCHEMBL4029452 | 0.69 | EGFR (0.60) | EGFRERBB2SRCKCNH2KDR | |
| SCHEMBL6621804 | 0.68 | ERBB2 (0.41) | EGFRERBB2SRCKCNH2KDR | |
| SCHEMBL6621126 | 0.66 | EGFR (0.40) | EGFRERBB2SRCKCNH2KDR | |
| SCHEMBL6618997 | 0.66 | EGFR (0.49) | EGFRERBB2SRCKCNH2KDR | |
| SCHEMBL6620697 | 0.66 | SLC6A2 (0.42) | EGFRERBB2SRCKCNH2KDR | |
| SCHEMBL4033918 | 0.65 | EGFR (0.65) | EGFRERBB2SRCKCNH2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |
| EP-1444211-A2 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040109-A2 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |