Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 15/20 | 0.65 |
| ▸ | RAB9A | P51151 | 15/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 14/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6384896 | 0.99 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL7538471 | 0.92 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR | |
| Lithium Ion SCHEMBL6384886 | 0.86 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL3517537 | 0.86 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL5717831 | 0.83 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL8900290 | 0.81 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL1812927 | 0.81 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL5206454 | 0.79 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL334041 | 0.78 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL8889364 | 0.78 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | disclosed |
| US-6903085-B1 | Substituted piperidine compounds useful as modulators of chemokine receptor activity | ASTRAZENECA, AB (CH) | 2005-06-07 | — | — | US | disclosed |
| EP-1212299-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca UK Limited (GB) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014333-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LIMITED (GB) | 2001-03-01 | — | — | WO | disclosed |