Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 16/20 | 0.68 |
| ▸ | RAB9A | P51151 | 16/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 15/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 5/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.58 |
| ▸ | RELA | Q04206 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 3/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334041 | 0.83 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4034138 | 0.81 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL11947463 | 0.81 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7976807 | 0.81 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6384896 | 0.80 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| Lithium Ion SCHEMBL6384886 | 0.79 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL3517537 | 0.79 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4109085 | 0.78 | NPC1 (0.80) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4037120 | 0.78 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL26525964 | 0.78 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |