Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 14/20 | 0.67 |
| ▸ | PLK1 | P53350 | 9/20 | 0.66 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.65 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033774 | 0.87 | PLK1 (0.68) | IKBKEPLK1TBK1 | |
| SCHEMBL4032682 | 0.84 | IKBKE (0.67) | IKBKEPLK1TBK1 | |
| SCHEMBL4032804 | 0.84 | IKBKE (0.80) | IKBKEPLK1TBK1PLK3 | |
| SCHEMBL6214432 | 0.82 | PLK1 (0.84) | IKBKEPLK1PLK3 | |
| SCHEMBL4032265 | 0.80 | IKBKE (1.00) | IKBKEPLK1TBK1PLK3 | |
| SCHEMBL4038453 | 0.79 | IKBKE (1.00) | IKBKEPLK1TBK1PLK3 | |
| SCHEMBL4033041 | 0.79 | IKBKE (0.79) | IKBKEPLK1TBK1PLK3 | |
| Gsk-319347A SCHEMBL29493088 | 0.79 | IKBKE (1.00) | IKBKEPLK1TBK1PLK3 | |
| Gsk-319347A SCHEMBL29712606 | 0.79 | IKBKE (1.00) | IKBKEPLK1TBK1PLK3 | |
| Gsk-319347A SCHEMBL3413628 | 0.79 | IKBKE (1.00) | IKBKEPLK1TBK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720864-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LTD (GB) | 2009-05-06 | — | — | EP | claimed |