Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.84 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.84 |
| ▸ | CDK2 | P24941 | 2/20 | 0.68 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.67 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | CSF1R | P07333 | 1/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.67 |
| ▸ | KIT | P10721 | 1/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | FLT1 | P17948 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gsk-204925A SCHEMBL4367870 | 0.87 | PLK1 (1.00) | PLK1PLK3CDK2PLK4AURKA | |
| SCHEMBL6214929 | 0.87 | PLK1 (0.68) | PLK1PLK3MAP4K4CSF1RKDR | |
| SCHEMBL5058253 | 0.85 | PLK1 (0.82) | PLK1PLK3CDK2IKBKEPLK4 | |
| SCHEMBL5062103 | 0.85 | PLK1 (1.00) | PLK1PLK3CDK2PLK4AURKA | |
| SCHEMBL4033812 | 0.84 | PLK1 (0.81) | PLK1PLK3CDK2PLK4AURKA | |
| SCHEMBL14050260 | 0.83 | PLK1 (0.86) | PLK1PLK3CDK2PLK4AURKA | |
| SCHEMBL5058276 | 0.82 | PLK1 (0.82) | PLK1PLK3CDK2PLK4AURKA | |
| SCHEMBL5058358 | 0.82 | PLK1 (0.81) | PLK1PLK3CDK2PLK4AURKA | |
| SCHEMBL5062225 | 0.82 | PLK1 (1.00) | PLK1PLK3CDK2PLK4AURKA | |
| SCHEMBL4034533 | 0.82 | IKBKE (0.67) | PLK1PLK3IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546137-A1 | BENZIMIDAZOL-1-YL-THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | SmithKline Beecham Corporation (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004014899-A1 | THIOPHENE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-19 | — | — | WO | disclosed |