Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.88 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.88 |
| ▸ | CSF1R | P07333 | 3/20 | 0.88 |
| ▸ | KDR | P35968 | 3/20 | 0.88 |
| ▸ | NEK2 | P51955 | 3/20 | 0.88 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.88 |
| ▸ | STK3 | Q13188 | 3/20 | 0.88 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.88 |
| ▸ | BRSK1 | Q8TDC3 | 3/20 | 0.88 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.88 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.88 |
| ▸ | PLK4 | O00444 | 2/20 | 0.88 |
| ▸ | AURKA | O14965 | 2/20 | 0.88 |
| ▸ | JAK2 | O60674 | 2/20 | 0.88 |
| ▸ | LCK | P06239 | 2/20 | 0.88 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.88 |
| ▸ | SRC | P12931 | 2/20 | 0.88 |
| ▸ | FLT1 | P17948 | 2/20 | 0.88 |
| ▸ | CDK2 | P24941 | 2/20 | 0.88 |
| ▸ | AXL | P30530 | 2/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gw843682X SCHEMBL1286884 | 0.94 | PLK1 (1.00) | PLK1PLK3CSF1RKDRNEK2 | |
| Gw843682X SCHEMBL31416068 | 0.94 | PLK1 (1.00) | PLK1PLK3CSF1RKDRNEK2 | |
| Gw843682X SCHEMBL29432471 | 0.94 | PLK1 (1.00) | PLK1PLK3CSF1RKDRNEK2 | |
| SCHEMBL5058201 | 0.92 | PLK1 (0.88) | PLK1PLK3CSF1RKDRNEK2 | |
| SCHEMBL5063073 | 0.92 | PLK1 (0.84) | PLK1PLK3CSF1RKDRNEK2 | |
| SCHEMBL5058163 | 0.89 | PLK1 (0.81) | PLK1PLK3CSF1RKDRNEK2 | |
| SCHEMBL4041060 | 0.87 | PLK1 (0.78) | PLK1PLK3CSF1RKDRNEK2 | |
| SCHEMBL5067369 | 0.87 | PLK1 (0.78) | PLK1PLK3CSF1RKDRNEK2 | |
| SCHEMBL5058144 | 0.87 | PLK1 (0.75) | PLK1PLK3CSF1RKDRNEK2 | |
| SCHEMBL5058278 | 0.86 | PLK1 (1.00) | PLK1PLK3CSF1RKDRNEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720864-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LTD (GB) | 2009-05-06 | — | — | EP | disclosed |
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | GLAXO GROUP LIMITED (GB) | 2007-06-28 | — | — | US | disclosed |
| EP-1720864-A1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005075465-A1 | BENZIMIDAZOL SUBSTITUTED THIOPENE DERIVATIVES WITH ATCTIVITY ON IKK3 | GLAXO GROUP LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | IKBKE, IKBKB, TBK1 | PLK1 1088/4885PLK3 413/4885CSF1R 3611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.