Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenoxypropazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.96 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.96 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | SCN4A | P35499 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenoxypropazine SCHEMBL147198 | 0.98 | MAOA (1.00) | MAOAPTGS1MTNR1AMTNR1BLMNA | |
| Phenoxypropazine SCHEMBL6874344 | 0.96 | MAOA (0.96) | MAOAPTGS1MTNR1AMTNR1BLMNA | |
| Phenoxypropazine SCHEMBL6064655 | 0.96 | MAOA (0.96) | MAOAPTGS1MTNR1AMTNR1BLMNA | |
| Phenoxypropazine SCHEMBL5776663 | 0.91 | MAOA (0.86) | MAOAPTGS1MTNR1AMTNR1BLMNA | |
| Phenoxypropazine SCHEMBL20268628 | 0.84 | MAOA (0.73) | MAOAPTGS1MTNR1AMTNR1BLMNA | |
| SCHEMBL13212031 | 0.80 | MAOA (0.69) | MAOAPTGS1MTNR1AMTNR1BLMNA | |
| SCHEMBL11598862 | 0.80 | MAOA (0.69) | MAOAPTGS1MTNR1AMTNR1BLMNA | |
| SCHEMBL13996939 | 0.78 | MAOA (0.67) | MAOAPTGS1MTNR1AMTNR1BLMNA | |
| SCHEMBL11463788 | 0.78 | MAOA (0.65) | MAOAPTGS1MTNR1AMTNR1BLMNA | |
| SCHEMBL20385338 | 0.77 | MAOA (0.65) | MAOAPTGS1MTNR1AMTNR1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3887359-A1 | NOVEL TETRAZINE COMPOUNDS FOR IN VIVO IMAGING | Københavns Universitet (DK) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020108720-A1 | NOVEL TETRAZINE COMPOUNDS FOR IN VIVO IMAGING | Københavns Universitet (DK) | 2020-06-04 | — | — | WO | disclosed |
| WO-2014053402-A1 | METHOD FOR CONTROLLING NON-CROP PESTS | BASF SE (DE) | 2014-04-10 | — | — | WO | disclosed |
| EP-1611109-A4 | NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO LTD (JP) | 2009-06-24 | — | — | EP | disclosed |
| EP-1723135-A1 | NOVEL HYDROXY-6-HEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2006-11-22 | — | — | EP | disclosed |
| EP-1611109-A1 | NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-01-04 | — | — | EP | disclosed |
| WO-2005085225-A1 | NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-09-15 | — | — | WO | disclosed |
| WO-2004087680-A1 | NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |
| WO-1999031098-A1 | NOVEL PYRIDINE AND PYRIMIDINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1999-06-24 | — | — | WO | disclosed |
| WO-1997039007-A1 | COMPOUNDS AND METHODS FOR THE SELECTIVE TREATMENT OF CANCER AND BACTERIAL INFECTIONS | PRO-NEURON, INC. (US) | 1997-10-23 | — | — | WO | disclosed |
| EP-0404049-A2 | Process for etching polyimide resin | UBE INDUSTRIES, LTD. (JP) | 1990-12-27 | — | — | EP | disclosed |