Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.62 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 5/20 | 0.48 |
| ▸ | CCR1 | P32246 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040184 | 0.79 | SIGMAR1 (0.74) | SIGMAR1MCHR1 | |
| SCHEMBL8023864 | 0.77 | SIGMAR1 (1.00) | SIGMAR1CCR3 | |
| SCHEMBL6328866 | 0.76 | SIGMAR1 (0.70) | SIGMAR1MCHR1CCR3ALDH1A1 | |
| SCHEMBL4031095 | 0.75 | SIGMAR1 (0.74) | SIGMAR1CCR3CCR1 | |
| SCHEMBL4196888 | 0.75 | SIGMAR1 (0.62) | SIGMAR1MCHR1CCR3 | |
| SCHEMBL4201490 | 0.75 | CCR3 (0.66) | SIGMAR1MCHR1CCR3 | |
| SCHEMBL4206237 | 0.73 | SIGMAR1 (0.56) | SIGMAR1MCHR1CCR3 | |
| SCHEMBL4205936 | 0.72 | CCR3 (0.64) | MCHR1CCR3 | |
| SCHEMBL5120412 | 0.72 | SIGMAR1 (0.72) | SIGMAR1MCHR1CCR3CCR1 | |
| SCHEMBL4032574 | 0.71 | SIGMAR1 (0.77) | SIGMAR1MCHR1CCR3CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | claimed |
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | disclosed |