Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.78 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.78 |
| ▸ | KDR | P35968 | 7/20 | 0.78 |
| ▸ | GRK6 | P43250 | 8/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | GRK4 | P32298 | 2/20 | 0.49 |
| ▸ | GRK5 | P34947 | 2/20 | 0.49 |
| ▸ | GRK1 | Q15835 | 2/20 | 0.49 |
| ▸ | GRK7 | Q8WTQ7 | 2/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037330 | 0.92 | IGF1R (0.67) | IGF1RFGFR1KDRGRK6AURKA | |
| SCHEMBL4037280 | 0.88 | IGF1R (1.00) | IGF1RFGFR1KDRNTRK1 | |
| SCHEMBL2123925 | 0.87 | IGF1R (0.60) | IGF1RFGFR1KDRPTK2NTRK1 | |
| SCHEMBL4037341 | 0.85 | IGF1R (0.59) | IGF1RFGFR1KDRAURKAPTK2 | |
| SCHEMBL4038721 | 0.82 | IGF1R (0.79) | IGF1RFGFR1KDRNTRK1 | |
| SCHEMBL2120422 | 0.81 | IGF1R (0.64) | IGF1RFGFR1KDRAURKAPTK2 | |
| SCHEMBL4034969 | 0.80 | IGF1R (0.85) | IGF1RFGFR1KDRNTRK1 | |
| SCHEMBL2121100 | 0.77 | IGF1R (1.00) | IGF1RFGFR1KDRNTRK1 | |
| SCHEMBL1770945 | 0.76 | FGFR1 (0.46) | IGF1RFGFR1KDRGRK6AURKA | |
| SCHEMBL4031791 | 0.76 | IGF1R (0.79) | IGF1RFGFR1KDRAURKAPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |
| CN-1289486-C | Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-1) | ASTRAZENECA AB (SE) | 2006-12-13 | — | — | CN | disclosed |
| CN-1617858-A | Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-1) | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | CN | disclosed |