Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.67 |
| ▸ | KDR | P35968 | 10/20 | 0.67 |
| ▸ | INSR | P06213 | 2/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | GRK6 | P43250 | 2/20 | 0.43 |
| ▸ | GRK4 | P32298 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.43 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | FER | P16591 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034838 | 0.92 | IGF1R (0.78) | IGF1RFGFR1KDRPTK2NTRK1 | |
| SCHEMBL4034969 | 0.88 | IGF1R (0.85) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL2123925 | 0.85 | IGF1R (0.60) | IGF1RFGFR1KDRPTK2NTRK1 | |
| SCHEMBL4031791 | 0.84 | IGF1R (0.79) | IGF1RFGFR1KDRINSRPTK2 | |
| SCHEMBL4037341 | 0.83 | IGF1R (0.59) | IGF1RFGFR1KDRPTK2NTRK1 | |
| SCHEMBL2120422 | 0.81 | IGF1R (0.64) | IGF1RFGFR1KDRINSRPTK2 | |
| SCHEMBL4038721 | 0.80 | IGF1R (0.79) | IGF1RFGFR1KDRNTRK1 | |
| SCHEMBL4037280 | 0.80 | IGF1R (1.00) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4040276 | 0.77 | FGFR1 (0.46) | IGF1RFGFR1KDRINSRPTK2 | |
| SCHEMBL2121100 | 0.76 | IGF1R (1.00) | IGF1RFGFR1KDRINSRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |