Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 10/20 | 0.41 |
| ▸ | BRAF | P15056 | 10/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037276 | 0.94 | KDR (0.43) | KDRFLT1TP53MAPTKIT | |
| SCHEMBL4035003 | 0.89 | KDR (0.45) | KDRFLT1TP53MAPTKIT | |
| SCHEMBL4037147 | 0.89 | KDR (0.43) | KDRFLT1TP53MAPTHPGDS | |
| SCHEMBL4037293 | 0.87 | KIT (0.51) | KDRFLT1TP53MAPTKIT | |
| SCHEMBL4037145 | 0.83 | KDM4E (0.48) | KDRFLT1TP53MAPTHPGDS | |
| SCHEMBL4032277 | 0.82 | KDR (0.42) | KDRFLT1TP53MAPTHPGDS | |
| SCHEMBL4037432 | 0.82 | KDR (0.44) | KDRFLT1TP53MAPTHPGDS | |
| SCHEMBL4038213 | 0.81 | NPC1 (0.49) | TP53MAPTKITBRAFNPC1 | |
| SCHEMBL6542888 | 0.80 | KDR (0.43) | KDRFLT1TP53MAPTHPGDS | |
| SCHEMBL4036769 | 0.76 | FLT1 (0.48) | KDRFLT1KITBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392680-B1 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | BAYER SCHERING PHARMA AG (DE) | 2009-07-22 | — | — | EP | disclosed |