Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 8/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038096 | 0.82 | KDM4E (0.46) | HSP90AA1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3706068 | 0.80 | MAPT (0.52) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL4033669 | 0.80 | LPAR1 (0.72) | HSP90AA1HSP90AB1PDK1LPAR1 | |
| SCHEMBL12465676 | 0.77 | POLB (0.48) | KDM4EMAPTLPAR1 | |
| SCHEMBL4037272 | 0.76 | MAPT (0.54) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL4033885 | 0.76 | LPAR1 (0.52) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL4032753 | 0.75 | TP53 (0.53) | KDM4EMAPTLPAR1 | |
| SCHEMBL4037667 | 0.75 | LPAR1 (0.48) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL2761636 | 0.75 | MAPT (0.53) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL4035675 | 0.74 | MAPT (0.67) | HTTSMN1; SMN2KDM4EMAPTLPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |