Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.65 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.48 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.48 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.48 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5529169 | 0.89 | MAPT (0.62) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL4037272 | 0.89 | MAPT (0.54) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL2761636 | 0.87 | MAPT (0.53) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL4028773 | 0.87 | MAPT (0.53) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL4034814 | 0.86 | MAPT (0.53) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL12465807 | 0.86 | MAPT (0.52) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL12467498 | 0.86 | MAPT (0.52) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL4034870 | 0.86 | MAPT (0.52) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL3710978 | 0.86 | MAPT (0.52) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL6003 | 0.86 | LPAR1 (0.54) | MAPTKDM4ELPAR1LPAR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |