Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.61 |
| ▸ | KDR | P35968 | 10/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | LTK | P29376 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12431094 | 0.87 | IGF1R (0.54) | IGF1RFGFR1KDRINSRCLK4 | |
| SCHEMBL13636059 | 0.85 | IGF1R (0.53) | IGF1RFGFR1KDRINSRCLK4 | |
| SCHEMBL4827807 | 0.83 | IGF1R (0.60) | IGF1RFGFR1KDRINSRCLK4 | |
| SCHEMBL5480736 | 0.82 | IGF1R (0.55) | IGF1RFGFR1KDRINSRCLK4 | |
| SCHEMBL4034569 | 0.82 | IGF1R (0.66) | IGF1RFGFR1KDRINSRCLK4 | |
| SCHEMBL2123750 | 0.82 | IGF1R (0.85) | IGF1RFGFR1KDRINSRPAK4 | |
| SCHEMBL13639120 | 0.78 | IGF1R (0.51) | IGF1RFGFR1KDRINSRCLK4 | |
| SCHEMBL12430659 | 0.77 | NTRK1 (0.74) | IGF1RFGFR1KDRINSRAURKA | |
| SCHEMBL13639073 | 0.77 | AURKA (0.53) | IGF1RFGFR1KDRINSRCLK4 | |
| SCHEMBL24137531 | 0.76 | ITK (0.71) | IGF1RFGFR1KDRCLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |