Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.66 |
| ▸ | KDR | P35968 | 7/20 | 0.66 |
| ▸ | INSR | P06213 | 1/20 | 0.66 |
| ▸ | BCL6 | P41182 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.53 |
| ▸ | PAK4 | O96013 | 7/20 | 0.52 |
| ▸ | PLK4 | O00444 | 6/20 | 0.52 |
| ▸ | AURKA | O14965 | 4/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031791 | 0.88 | IGF1R (0.79) | IGF1RFGFR1KDRINSRBCL6 | |
| SCHEMBL2123750 | 0.87 | IGF1R (0.85) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4038016 | 0.87 | IGF1R (0.79) | IGF1RFGFR1KDRINSRBCL6 | |
| SCHEMBL2122674 | 0.87 | IGF1R (0.58) | IGF1RFGFR1KDRINSRBCL6 | |
| SCHEMBL4036060 | 0.83 | IGF1R (0.55) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4037067 | 0.82 | IGF1R (0.69) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4035128 | 0.82 | IGF1R (0.61) | IGF1RFGFR1KDRINSRPAK4 | |
| SCHEMBL3338201 | 0.81 | NTRK1 (0.59) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL3335945 | 0.81 | NTRK1 (0.72) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL12430659 | 0.80 | NTRK1 (0.74) | IGF1RFGFR1KDRINSRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |