Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.75 |
| ▸ | KIT | P10721 | 3/20 | 0.75 |
| ▸ | FLT4 | P35916 | 1/20 | 0.75 |
| ▸ | ILK | Q13418 | 1/20 | 0.75 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.75 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | STAT6 | P42226 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042267 | 0.93 | KIT (0.80) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037772 | 0.91 | KDR (0.83) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4035475 | 0.91 | KDR (0.82) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037126 | 0.90 | KIT (0.85) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4035972 | 0.90 | KDR (0.73) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037825 | 0.88 | KIT (0.86) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4035650 | 0.86 | KDR (0.84) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4039093 | 0.86 | KIT (0.81) | KDRPDGFRBKITFLT4ILK | |
| Telatinib SCHEMBL1250560 | 0.86 | KDR (1.00) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4035178 | 0.86 | KIT (0.84) | KDRPDGFRBKITFLT4ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228063-B1 | SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER CORP (US) | 2009-02-11 | — | — | EP | claimed |
| US-20050019424-A1 | Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives | BAYER HEALTHCARE LLC | 2005-01-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050019424-A1 | Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives | KDR, FLT4, FLT1 | KDR 1/4885PDGFRB 7/4885KIT 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.