Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.73 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.73 |
| ▸ | KIT | P10721 | 2/20 | 0.73 |
| ▸ | FLT4 | P35916 | 1/20 | 0.73 |
| ▸ | ILK | Q13418 | 1/20 | 0.73 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.73 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200989 | 0.91 | KDR (0.82) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4035151 | 0.90 | KDR (0.75) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037772 | 0.90 | KDR (0.83) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4035475 | 0.89 | KDR (0.82) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4035178 | 0.86 | KIT (0.84) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4042267 | 0.86 | KIT (0.80) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037825 | 0.86 | KIT (0.86) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037065 | 0.86 | KIT (0.75) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4038778 | 0.86 | KIT (0.69) | KDRPDGFRBKITFLT4ILK | |
| SCHEMBL4037126 | 0.85 | KIT (0.85) | KDRPDGFRBKITFLT4ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228063-B1 | SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER CORP (US) | 2009-02-11 | — | — | EP | claimed |