Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3902571 | 0.82 | SIRT2 (0.53) | SIRT2CTSLCTSSSIRT1SIRT3 | |
| SCHEMBL13434967 | 0.82 | SIRT2 (0.53) | SIRT2CTSLCTSSSIRT1SIRT3 | |
| SCHEMBL133032 | 0.82 | SIRT2 (0.53) | SIRT2CTSLCTSSSIRT1SIRT3 | |
| SCHEMBL8054994 | 0.81 | SIRT2 (0.55) | SIRT2CTSLCTSSSIRT1SIRT3 | |
| SCHEMBL6024219 | 0.80 | CNR2 (0.43) | — | |
| SCHEMBL130760 | 0.80 | MEN1 (0.51) | SIRT2CTSLCTSSSIRT1SIRT3 | |
| SCHEMBL1596691 | 0.79 | CTSL (0.52) | SIRT2CTSLCTSSSIRT1SIRT3 | |
| SCHEMBL1734009 | 0.79 | CTSL (0.56) | SIRT2CTSLCTSSSIRT1HSD17B10 | |
| SCHEMBL3319289 | 0.79 | CTSL (0.56) | SIRT2CTSLCTSSSIRT1HSD17B10 | |
| SCHEMBL4542544 | 0.77 | SMN1; SMN2 (0.54) | SIRT2CTSLCTSSSIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585518-A4 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2009-04-22 | — | — | EP | disclosed |
| EP-1585518-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2005032550-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |