Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 11/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 10/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040312 | 0.86 | IKBKE (0.42) | PLK1IKBKETBK1FGFR1SRC | |
| SCHEMBL4036831 | 0.85 | PLK1 (0.46) | PLK1IKBKETBK1FGFR1SRC | |
| SCHEMBL4040575 | 0.82 | IKBKE (0.40) | PLK1IKBKETBK1FGFR1SRC | |
| SCHEMBL4037133 | 0.82 | IKBKE (0.37) | PLK1IKBKETBK1FGFR1SRC | |
| SCHEMBL4032649 | 0.82 | IKBKE (0.39) | PLK1IKBKETBK1FGFR1SRC | |
| SCHEMBL4034367 | 0.81 | PLK1 (0.44) | PLK1IKBKETBK1FGFR1SRC | |
| SCHEMBL4035204 | 0.80 | IKBKE (0.38) | PLK1IKBKETBK1FGFR1SRC | |
| SCHEMBL4032684 | 0.80 | FGFR1 (0.43) | PLK1IKBKETBK1FGFR1SRC | |
| SCHEMBL4034652 | 0.79 | PLK1 (0.57) | PLK1IKBKETBK1FGFR1SRC | |
| SCHEMBL4033043 | 0.79 | PLK1 (0.48) | PLK1IKBKETBK1FGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720864-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LTD (GB) | 2009-05-06 | — | — | EP | claimed |