Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 10/20 | 0.50 |
| ▸ | CTSK | P43235 | 8/20 | 0.50 |
| ▸ | CTSB | P07858 | 4/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4839064 | 0.87 | CTSS (0.49) | CTSSCTSKCTSBCTSL | |
| SCHEMBL14436615 | 0.87 | CTSS (0.49) | CTSSCTSKCTSBCTSL | |
| SCHEMBL4839068 | 0.87 | CTSS (0.49) | CTSSCTSKCTSBCTSL | |
| SCHEMBL321049 | 0.85 | CTSS (0.50) | CTSSCTSKCTSBCTSL | |
| SCHEMBL4968810 | 0.85 | CTSS (0.50) | CTSSCTSKCTSBCTSL | |
| SCHEMBL321050 | 0.85 | CTSS (0.50) | CTSSCTSKCTSBCTSL | |
| SCHEMBL4499875 | 0.85 | CTSS (0.53) | CTSSCTSKCTSBCTSLFOLH1 | |
| SCHEMBL4839075 | 0.85 | CTSS (0.53) | CTSSCTSKCTSBCTSLFOLH1 | |
| SCHEMBL4968776 | 0.84 | CTSS (0.46) | CTSSCTSKCTSBCTSL | |
| SCHEMBL6164195 | 0.83 | CTSS (0.51) | CTSSCTSKCTSBCTSLFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |