Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.52 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.52 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.52 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.52 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035675 | 0.86 | MAPT (0.67) | MAPTKDM4EIP6K1IP6K3IP6K2 | |
| SCHEMBL4037473 | 0.86 | MAPT (0.51) | MAPTKDM4EIP6K1IP6K3IP6K2 | |
| SCHEMBL4030049 | 0.86 | MAPT (0.60) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL4031711 | 0.83 | MAPT (0.51) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL4037272 | 0.82 | MAPT (0.54) | MAPTKDM4EIP6K1IP6K3IP6K2 | |
| SCHEMBL4030546 | 0.82 | MAPT (0.47) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL4030555 | 0.82 | MAPT (0.47) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL4027907 | 0.81 | LPAR1 (0.83) | MAPTKDM4EIP6K1IP6K3IP6K2 | |
| SCHEMBL4032711 | 0.81 | LPAR1 (0.48) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL4029111 | 0.80 | LPAR1 (0.47) | MAPTKDM4ELPAR1LPAR3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |