Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.55 |
| ▸ | JAK1 | P23458 | 6/20 | 0.55 |
| ▸ | ULK1 | O75385 | 4/20 | 0.55 |
| ▸ | AURKA | O14965 | 4/20 | 0.54 |
| ▸ | TTK | P33981 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.48 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.48 |
| ▸ | MARK3 | P27448 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | FLT4 | P35916 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL921534 | 0.99 | JAK2 (0.54) | JAK2JAK1ULK1AURKATTK | |
| SCHEMBL12907285 | 0.87 | JAK2 (0.67) | JAK2JAK1ULK1AURKATTK | |
| SCHEMBL12907278 | 0.87 | JAK2 (0.55) | JAK2JAK1ULK1AURKATTK | |
| SCHEMBL4130093 | 0.84 | AURKA (0.54) | JAK2JAK1ULK1AURKAROCK2 | |
| SCHEMBL12907138 | 0.82 | JAK2 (0.55) | JAK2JAK1ULK1AURKATTK | |
| SCHEMBL12907141 | 0.80 | JAK2 (0.50) | JAK2JAK1ULK1AURKATTK | |
| SCHEMBL12907385 | 0.78 | SGK1 (0.48) | JAK2JAK1 | |
| SCHEMBL12907273 | 0.78 | ROCK2 (0.62) | JAK2AURKATTKCDK2PLK4 | |
| SCHEMBL12907292 | 0.78 | TTK (0.53) | JAK2JAK1ULK1TTKROCK2 | |
| SCHEMBL12907286 | 0.77 | JAK2 (0.66) | JAK2JAK1ULK1AURKATTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | claimed |
| US-20070232620-A1 | 3-Aminoindazoles | MERCK PATENT GMBH (DE) | 2007-10-04 | — | — | US | claimed |
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |
| US-7527655-B1 | Reactive ink jet ink printing process | SAWGRASS TECHNOLOGIES, INC. (US) | 2009-05-05 | — | — | US | disclosed |
| US-20090021568-A1 | Reactive Dye and Process of Printing Same | XU MING | 2009-01-22 | — | — | US | disclosed |
| US-20070232620-A1 | 3-Aminoindazoles | MERCK PATENT GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| US-20070232620-A1 | 3-Aminoindazoles | MERCK PATENT GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| EP-1765788-A2 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GmbH (DE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123688-A2 | 3-AMINOINDAZOLES | MERCK PATENT GMBH (DE) | 2005-12-29 | — | — | WO | disclosed |
| US-6961076-B2 | Reactive dye printing process | SAWGRASS TECHNOLOGIES, INC. | 2005-11-01 | — | — | US | disclosed |
| US-6840614-B2 | Reactive dye printing process | SAWGRASS TECHNOLOGIES, INC. | 2005-01-11 | — | — | US | disclosed |
| US-20040219296-A1 | Reactive dye printing process | SAWGRASS TECHNOLOGIES, INC. | 2004-11-04 | — | — | US | disclosed |
| US-20020101500-A1 | Reactive dye printing process | SAWGRASS TECHNOLOGIES, INC. | 2002-08-01 | — | — | US | disclosed |
| EP-1194298-A1 | USE OF REACTIVE DYE IN A THERMAL TRANSFER PRINTING PROCESS | SAWGRASS SYSTEMS, INC. (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6348939-B1 | Digital printable reactive dye and process | SAWGRASS SYSTEMS, INC. | 2002-02-19 | — | — | US | disclosed |
| US-20020012038-A1 | DIGITAL PRINTABLE REACTIVE DYE AND PROCESS | SAWGRASS TECHNOLOGIES, INC. | 2002-01-31 | — | — | US | disclosed |
| WO-2000073084-A1 | USE OF REACTIVE DYE IN A THERMAL TRANSFER PRINTING PROCESS | SAWGRASS SYSTEMS, INC. (US) | 2000-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232620-A1 | 3-Aminoindazoles | SGK3, SGK1, SGK2 | JAK2 562/4885JAK1 343/4885ULK1 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.