SCHEMBL4035940

SCHEMBL4035940

O=C(O)c1ccc(C(Br)c2ccc(Cl)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.68
ALOX15 P16050 1/20 0.68
SRD5A2 P31213 4/20 0.61
ALDH1A1 P00352 1/20 0.50
TP53 P04637 1/20 0.48
CES2 O00748 2/20 0.46
CES1 P23141 2/20 0.46
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
NR4A2 P43354 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
RXRA P19793 1/20 0.46
RXRB P28702 1/20 0.46
GSK3B P49841 1/20 0.44
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
SRD5A1 P18405 1/20 0.43
ANPEP P15144 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4642822 0.89 TSHR (0.60) TSHRALOX15SRD5A2ALDH1A1TP53
4-Chloro-Benzoic Acid SCHEMBL1331727 0.82 TSHR (1.00) TSHRALOX15SRD5A2ALDH1A1TP53
4-Chloro-Benzoic Acid SCHEMBL28384 0.82 TSHR (1.00) TSHRALOX15SRD5A2ALDH1A1TP53
SCHEMBL4030936 0.82 TSHR (0.71) TSHRALOX15SRD5A2ALDH1A1TP53
4-Chloro-Benzoic Acid SCHEMBL7634885 0.80 TSHR (0.94) TSHRALOX15SRD5A2ALDH1A1TP53
4-Chloro-Benzoic Acid SCHEMBL3150134 0.80 TSHR (0.94) TSHRALOX15SRD5A2ALDH1A1TP53
4-Chloro-Benzoic Acid SCHEMBL9120766 0.80 TSHR (0.94) TSHRALOX15SRD5A2ALDH1A1TP53
4-Chloro-Benzoic Acid SCHEMBL9493329 0.80 TSHR (0.94) TSHRALOX15SRD5A2ALDH1A1TP53
4-Chloro-Benzoic Acid SCHEMBL2918294 0.80 TSHR (0.94) TSHRALOX15SRD5A2ALDH1A1TP53
4-Chloro-Benzoic Acid SCHEMBL11173042 0.80 TSHR (0.94) TSHRALOX15SRD5A2ALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1263720-B1 AZETIDINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AVENTIS PHARMA SA (FR) 2009-06-03 EP disclosed
EP-1112251-B1 AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM AVENTIS PHARMA SA (FR) 2003-05-07 EP disclosed
EP-1263720-A1 AZETIDINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Aventis Pharma S.A. (FR) 2002-12-11 EP disclosed
WO-2001064632-A1 AZETIDINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AVENTIS PHARMA S.A. (FR) 2001-09-07 WO disclosed
EP-1112251-A1 AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM Aventis Pharma S.A. (FR) 2001-07-04 EP disclosed
WO-2000015609-A1 AZETIDINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM AVENTIS PHARMA S.A. (FR) 2000-03-23 WO disclosed