Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.64 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | PTGIR | P43119 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14851887 | 0.85 | HDAC1 (0.74) | HDAC1HDAC6HDAC8HDAC3HDAC10 | |
| SCHEMBL16125620 | 0.83 | HDAC6 (0.63) | HDAC1HDAC6HDAC8HDAC3HDAC10 | |
| SCHEMBL446016 | 0.80 | HDAC6 (0.53) | HDAC1HDAC6HDAC8HDAC3HDAC10 | |
| SCHEMBL14851960 | 0.78 | HDAC1 (0.57) | HDAC1HDAC6HDAC8HDAC3HDAC10 | |
| SCHEMBL447520 | 0.78 | HDAC6 (0.53) | HDAC1HDAC6HDAC8HDAC3HDAC10 | |
| SCHEMBL14851795 | 0.78 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC10 | |
| SCHEMBL5020665 | 0.77 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC10 | |
| SCHEMBL16125627 | 0.76 | HDAC1 (0.55) | HDAC1HDAC6HDAC8HDAC3HDAC10 | |
| SCHEMBL10533853 | 0.76 | THRA (0.60) | — | |
| SCHEMBL16125595 | 0.76 | HDAC1 (0.81) | HDAC1HDAC6HDAC8HDAC3HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611088-B1 | HYDROXAMATES AS THERAPEUTIC AGENTS | PHARMACYCLICS INC (US) | 2009-06-17 | — | — | EP | claimed |