Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 12/20 | 0.45 |
| ▸ | CCR1 | P32246 | 4/20 | 0.39 |
| ▸ | CCR8 | P51685 | 4/20 | 0.39 |
| ▸ | CCR5 | P51681 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035600 | 0.90 | TGFBR1 (0.43) | TGFBR1CCR1CCR8CCR5MAPT | |
| SCHEMBL4032702 | 0.83 | TGFBR1 (0.46) | TGFBR1CCR1CCR8CCR5MAPT | |
| SCHEMBL30135394 | 0.80 | CCR1 (0.52) | TGFBR1CCR1CCR8CCR5MAPT | |
| SCHEMBL4034948 | 0.79 | TGFBR1 (0.45) | TGFBR1CCR1CCR8CCR5MAPT | |
| SCHEMBL4032549 | 0.76 | TGFBR1 (0.53) | TGFBR1 | |
| SCHEMBL4030528 | 0.75 | TGFBR1 (0.57) | TGFBR1CCR1CCR8 | |
| SCHEMBL4035172 | 0.75 | TGFBR1 (0.57) | TGFBR1CCR1CCR8 | |
| SCHEMBL4035598 | 0.71 | TGFBR1 (0.51) | TGFBR1MTOR | |
| SCHEMBL4031270 | 0.70 | TGFBR1 (0.62) | TGFBR1MTOR | |
| SCHEMBL4031950 | 0.70 | MAPK14 (0.40) | TGFBR1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542994-B1 | NOVEL OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR | PFIZER PROD INC (US) | 2009-04-29 | — | — | EP | claimed |