Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 19/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040325 | 0.91 | LCK (0.73) | LCKSRC | |
| SCHEMBL4036351 | 0.86 | LCK (0.69) | LCKSRC | |
| SCHEMBL4039733 | 0.86 | LCK (0.75) | LCKSRC | |
| SCHEMBL4037424 | 0.86 | LCK (0.75) | LCKSRC | |
| SCHEMBL4041102 | 0.84 | LCK (0.68) | LCKSRC | |
| SCHEMBL4038195 | 0.84 | LCK (0.75) | LCKSRC | |
| SCHEMBL4039788 | 0.84 | LCK (0.75) | LCKSRC | |
| SCHEMBL4045378 | 0.84 | LCK (0.72) | LCKSRC | |
| SCHEMBL4038851 | 0.83 | LCK (0.69) | LCKSRC | |
| SCHEMBL4036075 | 0.83 | LCK (0.76) | LCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |