SCHEMBL4036553

SCHEMBL4036553

COc1cc(C2(C(C(=O)NC3CCCCC3)C3CCCCC3)Nc3ccccc3N2)ccc1C

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.45
L3MBTL1 Q9Y468 3/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ALDH1A1 P00352 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
CTSD P07339 1/20 0.39
BCHE P06276 1/20 0.39
ACHE P22303 1/20 0.39
CNR1 P21554 1/20 0.39
CNR2 P34972 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4036857 0.92 HPGD (0.43) HPGDL3MBTL1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL4037807 0.92 CTSD (0.46) HPGDL3MBTL1RAB9AALDH1A1MEN1
SCHEMBL4039067 0.89 NPC1 (0.44) HPGDRAB9ASMN1; SMN2ALDH1A1MEN1
SCHEMBL4037831 0.88 KMT2A (0.42) HPGDL3MBTL1RAB9AALDH1A1MEN1
SCHEMBL4040352 0.87 KMT2A (0.44) HPGDL3MBTL1RAB9AALDH1A1MEN1
SCHEMBL4037528 0.87 KMT2A (0.44) HPGDL3MBTL1RAB9AALDH1A1MEN1
SCHEMBL4044713 0.87 KMT2A (0.44) HPGDRAB9ASMN1; SMN2ALDH1A1MEN1
SCHEMBL4040812 0.86 CNR1 (0.47) HPGDL3MBTL1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL4044492 0.85 KMT2A (0.42) HPGDRAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL4039515 0.84 EPHX1 (0.44) HPGDL3MBTL1RAB9ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP disclosed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO disclosed