Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.71 |
| ▸ | KDR | P35968 | 12/20 | 0.71 |
| ▸ | INSR | P06213 | 4/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041062 | 0.85 | IGF1R (0.77) | IGF1RFGFR1KDRINSRJAK2 | |
| SCHEMBL4034616 | 0.84 | IGF1R (0.76) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL2121100 | 0.83 | IGF1R (1.00) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL2122619 | 0.83 | IGF1R (1.00) | IGF1RFGFR1KDRINSRJAK2 | |
| SCHEMBL4037935 | 0.81 | IGF1R (0.72) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4042036 | 0.79 | IGF1R (0.65) | IGF1RFGFR1KDRINSRJAK2 | |
| SCHEMBL2123750 | 0.79 | IGF1R (0.85) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4033932 | 0.78 | IGF1R (0.67) | IGF1RFGFR1KDRINSRJAK2 | |
| SCHEMBL4033906 | 0.77 | IGF1R (0.79) | IGF1RFGFR1KDRINSRPLK4 | |
| SCHEMBL2121493 | 0.77 | IGF1R (1.00) | IGF1RFGFR1KDRINSRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |