Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4042312 | 0.90 | HTR2A (0.40) | CSNK1EHTR2AHTR2C | |
| Trifluoroacetic Acid SCHEMBL4039701 | 0.85 | CYP11B2 (0.33) | HTR2AHTR2CCYP11B2CYP11B1 | |
| Trifluoroacetic Acid SCHEMBL4043668 | 0.83 | MKNK1 (0.34) | MKNK1MKNK2CSNK1DCSNK1EDPP4 | |
| Trifluoroacetic Acid SCHEMBL4036958 | 0.81 | MKNK1 (0.36) | MKNK1MKNK2CSNK1DCSNK1EDPP4 | |
| SCHEMBL4040261 | 0.79 | MKNK1 (0.42) | MKNK1MKNK2CSNK1DCSNK1EHTR2A | |
| SCHEMBL7954819 | 0.78 | KDM4E (0.42) | MKNK1MKNK2CSNK1DCSNK1EKDM4E | |
| Trifluoroacetic Acid SCHEMBL4039390 | 0.77 | HTR2A (0.32) | HTR2AHTR2C | |
| Trifluoroacetic Acid SCHEMBL4036264 | 0.75 | HTR2A (0.40) | CSNK1EHTR2AHTR2C | |
| SCHEMBL4047712 | 0.75 | MKNK1 (0.38) | MKNK1MKNK2CSNK1DCSNK1EHTR2A | |
| Trifluoroacetic Acid SCHEMBL4038370 | 0.74 | CSNK1E (0.36) | CSNK1DCSNK1EHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463728-B1 | FUSED CYCLIC MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-1436291-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | Aventis Pharma S.A. (FR) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003024967-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2003-03-27 | — | — | WO | disclosed |