Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917467 | 1.00 | PPM1B (0.56) | PPM1BPTPN1PPP1CCPOLBCYP2C19 | |
| SCHEMBL257600 | 1.00 | PPM1B (0.56) | PPM1BPTPN1PPP1CCPOLBCYP2C19 | |
| SCHEMBL5490936 | 1.00 | PPM1B (0.56) | PPM1BPTPN1PPP1CCPOLBCYP2C19 | |
| SCHEMBL20075282 | 0.87 | CYP2C19 (0.50) | PPM1BPTPN1PPP1CCPOLBCYP2C19 | |
| SCHEMBL2081942 | 0.87 | CYP2C19 (0.50) | PPM1BPTPN1PPP1CCPOLBCYP2C19 | |
| SCHEMBL13139972 | 0.87 | CYP2C19 (0.50) | PPM1BPTPN1PPP1CCPOLBCYP2C19 | |
| SCHEMBL2080386 | 0.87 | CYP2C19 (0.50) | PPM1BPTPN1PPP1CCPOLBCYP2C19 | |
| SCHEMBL8919476 | 0.87 | CYP2C19 (0.50) | PPM1BPTPN1PPP1CCPOLBCYP2C19 | |
| SCHEMBL15319047 | 0.81 | PPM1B (0.50) | PPM1BPTPN1PPP1CCPOLBCYP2C19 | |
| SCHEMBL392329 | 0.79 | PPM1B (0.59) | PPM1BPTPN1PPP1CCPOLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250114457-A1 | PHARMACEUTICAL COMPOSITIONS OF FUMARIC ACID ESTERS | HPS INVESTMENT PARTNERS, LLC, AS ADMINISTRATIVE AGENT | 2025-04-10 | — | — | US | claimed |
| US-20220241420-A1 | Pharmaceutical Compositions of Fumaric Acid Esters | ARBOR PHARMACEUTICALS, LLC | 2022-08-04 | — | — | US | claimed |
| US-9999672-B2 | Pharmaceutical compositions of fumaric acid esters | XENOPORT, INC. (US) | 2018-06-19 | — | — | US | claimed |
| US-20150265707-A1 | PHARMACEUTICAL COMPOSITIONS OF FUMARIC ACID ESTERS | HPS INVESTMENT PARTNERS, LLC, AS ADMINISTRATIVE AGENT | 2015-09-24 | — | — | US | claimed |
| WO-2014160633-A1 | PHARMACEUTICAL COMPOSITIONS OF DIMETHYL FUMARATE | XENOPORT, INC. (US) | 2014-10-02 | — | — | WO | claimed |
| EP-1592436-A4 | COMPOUNDS THAT BIND P2Y sb 2 /sb OR P2Y sb 1 /sb RECEPTORS | KIMBERLY CLARK CO (US) | 2009-09-02 | — | — | EP | claimed |
| US-7056889-B2 | Compounds that bind P2Y2 or P2Y1 receptors | KIMBERLY-CLARK, WORLDWIDE, INC. (US) | 2006-06-06 | — | — | US | claimed |
| EP-1592436-A2 | COMPOUNDS THAT BIND P2Y sb 2 /sb OR P2Y sb 1 /sb RECEPTORS | Kimberly-Clark Worldwide, Inc. (US) | 2005-11-09 | — | — | EP | claimed |
| WO-2004060907-A2 | COMPOUNDS THAT BIND P2Y2 OR P2Y1 RECEPTORS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2004-07-22 | — | — | WO | claimed |
| US-20040116339-A1 | Compounds that bind P2Y2 or P2Y1 receptors | KIMBERLY-CLARK WORLDWIDE, INC. | 2004-06-17 | — | — | US | claimed |
| US-20250114457-A1 | PHARMACEUTICAL COMPOSITIONS OF FUMARIC ACID ESTERS | HPS INVESTMENT PARTNERS, LLC, AS ADMINISTRATIVE AGENT | 2025-04-10 | — | — | US | disclosed |
| US-20220241420-A1 | Pharmaceutical Compositions of Fumaric Acid Esters | ARBOR PHARMACEUTICALS, LLC | 2022-08-04 | — | — | US | disclosed |
| US-11135296-B2 | Pharmaceutical compositions of fumaric acid esters | ARBOR PHARMACEUTICALS, LLC (US) | 2021-10-05 | — | — | US | disclosed |
| US-20190117776-A1 | Pharmaceutical Compositions of Fumaric Acid Esters | HPS INVESTMENT PARTNERS, LLC, AS ADMINISTRATIVE AGENT | 2019-04-25 | — | — | US | disclosed |
| US-9999672-B2 | Pharmaceutical compositions of fumaric acid esters | XENOPORT, INC. (US) | 2018-06-19 | — | — | US | disclosed |
| WO-2004060907-A2 | COMPOUNDS THAT BIND P2Y2 OR P2Y1 RECEPTORS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2004-07-22 | — | — | WO | disclosed |
| US-20040116339-A1 | Compounds that bind P2Y2 or P2Y1 receptors | KIMBERLY-CLARK WORLDWIDE, INC. | 2004-06-17 | — | — | US | disclosed |
| EP-0677039-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 1999-03-10 | — | — | EP | disclosed |
| EP-0677039-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11135296-B2 | Pharmaceutical compositions of fumaric acid esters | FAH, FH, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | PPM1B 1070/4885PTPN1 1581/4885PPP1CC 2697/4885 |
| US-20150265707-A1 | PHARMACEUTICAL COMPOSITIONS OF FUMARIC ACID ESTERS | FAH, FH, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | PPM1B 1070/4885PTPN1 1581/4885PPP1CC 2697/4885 |
| US-20250114457-A1 | PHARMACEUTICAL COMPOSITIONS OF FUMARIC ACID ESTERS | FAH, FH, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | PPM1B 1070/4885PTPN1 1581/4885PPP1CC 2697/4885 |
| US-20220241420-A1 | Pharmaceutical Compositions of Fumaric Acid Esters | FAH, FH, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | PPM1B 1070/4885PTPN1 1581/4885PPP1CC 2697/4885 |
| US-20190117776-A1 | Pharmaceutical Compositions of Fumaric Acid Esters | FAH, FH, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | PPM1B 1070/4885PTPN1 1581/4885PPP1CC 2697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.