Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 7/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.63 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | METAP2 | P50579 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | METAP1 | P53582 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | WNT1 | P04628 | 2/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.57 |
| ▸ | CLK2 | P49760 | 1/20 | 0.57 |
| ▸ | CLK3 | P49761 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 3/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17594418 | 0.88 | WNT1 (0.51) | PDPK1FGFR1FLT1CHEK1WNT1 | |
| SCHEMBL3533024 | 0.87 | PDPK1 (0.73) | PDPK1FGFR1FLT1CHEK1WNT1 | |
| SCHEMBL5508118 | 0.85 | PDPK1 (0.74) | PDPK1FGFR1FLT1CHEK1NPC1 | |
| SCHEMBL14493653 | 0.84 | MAP3K8 (0.66) | PDPK1FGFR1FLT1CHEK1WNT1 | |
| SCHEMBL17566751 | 0.83 | WNT1 (0.70) | PDPK1FGFR1FLT1CHEK1NPC1 | |
| SCHEMBL17588534 | 0.82 | DYRK1A (0.66) | NPC1HPGDRAB9ASMN1; SMN2WNT1 | |
| SCHEMBL15868921 | 0.82 | PDPK1 (0.64) | PDPK1FGFR1FLT1CHEK1WNT1 | |
| SCHEMBL5513046 | 0.81 | CDK4 (0.67) | PDPK1FGFR1FLT1CHEK1CDK4 | |
| SCHEMBL18446639 | 0.81 | CLK3 (0.54) | WNT1CLK2CLK3DYRK1ALRRK2 | |
| SCHEMBL15869066 | 0.80 | WNT1 (0.73) | PDPK1FGFR1FLT1CHEK1WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541367-B2 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-06-02 | — | — | US | disclosed |
| US-20090048249-A1 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-02-19 | — | — | US | disclosed |
| WO-2006130673-A1 | 3-BENZOIMIDAZOLYL-PYRAZOLOPYRIDINES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048249-A1 | 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders | PRKDC, PRKACA, ABL1 | PDPK1 90/4885FGFR1 508/4885FLT1 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.