Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 0.52 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | KDR | P35968 | 10/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3282184 | 0.86 | SRC (0.66) | SRCEGFRKDR | |
| SCHEMBL1012776 | 0.81 | EGFR (0.62) | SRCEGFRKDR | |
| SCHEMBL3281890 | 0.78 | EGFR (0.52) | SRCEGFRKDR | |
| SCHEMBL1803647 | 0.74 | SRC (0.56) | SRCEGFR | |
| SCHEMBL30353909 | 0.74 | SRC (0.56) | SRCEGFR | |
| SCHEMBL3274806 | 0.74 | SRC (0.54) | SRCEGFRKDR | |
| SCHEMBL3274950 | 0.73 | HTR2C (0.53) | SRCEGFRKDR | |
| SCHEMBL30988686 | 0.73 | SRC (0.60) | SRCEGFRKDR | |
| SCHEMBL3182426 | 0.72 | ENPP1 (0.44) | SRCEGFRKDR | |
| SCHEMBL1810090 | 0.72 | ENPP1 (0.55) | SRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444211-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |