Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 13/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TOP2A | P11388 | 4/20 | 0.54 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1935815 | 0.98 | NISCH (0.59) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL2242209 | 0.90 | NISCH (0.68) | NISCHTOP2ATOP2BHTR1DADRA1A | |
| Hydrochloric Acid SCHEMBL2240002 | 0.89 | NISCH (0.66) | NISCHTOP2ATOP2BHTR1DADRA1A | |
| Hydrochloric Acid SCHEMBL15514136 | 0.89 | NISCH (0.66) | NISCHTOP2ATOP2BHTR1DADRA1A | |
| Hydrochloric Acid SCHEMBL2238276 | 0.89 | NISCH (0.66) | NISCHTOP2ATOP2BHTR1DADRA1A | |
| SCHEMBL13327264 | 0.81 | NISCH (0.81) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL18282371 | 0.79 | NISCH (0.62) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL23901774 | 0.79 | NISCH (0.53) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL23902290 | 0.76 | NISCH (0.50) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL11462790 | 0.76 | NISCH (1.00) | NISCHGAATSHRTOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521744-B1 | ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS B1 BRADYKININ RECEPTOR ANTAGONISTS | FOURNIER LAB SA (FR) | 2009-04-01 | — | — | EP | disclosed |
| US-7361687-B2 | Arylsulphonamide derivatives and methods of preparing | LABORATOIRES FOURNIER SA (FR) | 2008-04-22 | — | — | US | disclosed |
| US-20060084699-A1 | Novel arylsulphonamide derivatives and use thereof as therapeutic agents | LABORATOIRES FOURNIER SA (FR) | 2006-04-20 | — | — | US | disclosed |
| EP-1521744-A1 | ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS B1 BRADYKININ RECEPTOR ANTAGONISTS | LABORATOIRES FOURNIER S.A. (FR) | 2005-04-13 | — | — | EP | disclosed |
| WO-2003106428-A1 | NOVEL ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS THERAPEUTIC AGENTS | LABORATOIRES FOURNIER SA (FR) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084699-A1 | Novel arylsulphonamide derivatives and use thereof as therapeutic agents | UGT1A1, UGT2B7, UGT1A6 | NISCH 2280/4885GAA 215/4885TSHR 3038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.